Technische Universität München<p>Researchers developed synthetic mini-<a href="https://wisskomm.social/tags/proteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>proteins</span></a> that inhibit both <a href="https://wisskomm.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> formation in <a href="https://wisskomm.social/tags/Parkinsons" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Parkinsons</span></a> and harmful protein interactions between <a href="https://wisskomm.social/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a>, Parkinsons and <a href="https://wisskomm.social/tags/type2diabetes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>type2diabetes</span></a> in experimental models: <a href="http://go.tum.de/819859" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">http://</span><span class="">go.tum.de/819859</span><span class="invisible"></span></a> </p><p>📷A.Eckert</p>
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#Amyloid
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micronicle LAB<p>Experimenting with <a href="https://mastodon.social/tags/ThT" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ThT</span></a> stain on <a href="https://mastodon.social/tags/spider" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>spider</span></a> webs to see if it successfully bonds to the beta chain <a href="https://mastodon.social/tags/fibrin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fibrin</span></a> / <a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> like components. I've applied the stain and naturally under 460nm webs fluoresce the expected green. I'm waiting for the sample to completely dry before differentiating with alcohol and then using a water based mount to finally disassociate the unbounded stain from the webs and other artefacts. All being so, we might be left with ThT stained <a href="https://mastodon.social/tags/spidroins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>spidroins</span></a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://mastodon.social/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>biology</span></a> <a href="https://mastodon.social/tags/microscopy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microscopy</span></a></p>
WoollyMel<p><a href="https://toot.wales/tags/3goodthings" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>3goodthings</span></a> <br>Another sunny day<br>Lunch with some of my cousins to meet the cousin who lives in Thailand and has a Thai wife and daughter<br>Watched a documentary about <a href="https://toot.wales/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a> and <a href="https://toot.wales/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> research presented by Sally Magusson.</p>
DrBob, Neurologist, 🧠Mechanic<p>Did a new Alzheimer's drug keep this patient's brain healthier for longer?</p><p>New drugs Leqembi and Kisunla may have a modest benefit, don't cure <a href="https://vmst.io/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimer</span></a>'s, have a host of side effects (including brain bleeds), are troublesome to use (require IV infusion or injection) and multiple brain scans and cost 10's of thousands to administer.</p><p>"I think it helped," says her husband, Ken Bell. "But I'm not sure."</p><p>That sort of uncertainty is common when it comes to <a href="https://vmst.io/tags/Leqembi" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Leqembi</span></a> and <a href="https://vmst.io/tags/Kisunla" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Kisunla</span></a>…</p><p>Both drugs clear the brain of a substance called beta-<a href="https://vmst.io/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a>, which forms the sticky plaques associated with <a href="https://vmst.io/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a>. </p><p><a href="https://www.stlpr.org/npr/2025-02-26/did-a-new-alzheimers-drug-keep-this-patients-brain-healthier-for-longer" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">stlpr.org/npr/2025-02-26/did-a</span><span class="invisible">-new-alzheimers-drug-keep-this-patients-brain-healthier-for-longer</span></a></p>
John Vaccaro (johniac)<p>SciTech Chronicles. . . . . . . . .Feb 2nd, 2025</p><p><a href="https://bit.ly/stc020225" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">bit.ly/stc020225</span><span class="invisible"></span></a></p><p><a href="https://mastodon.social/tags/AM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AM</span></a> <a href="https://mastodon.social/tags/gastrointestinal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>gastrointestinal</span></a> <a href="https://mastodon.social/tags/mucus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mucus</span></a> <a href="https://mastodon.social/tags/glycan" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>glycan</span></a> <a href="https://mastodon.social/tags/mucin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>mucin</span></a> <a href="https://mastodon.social/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimer</span></a>’s <a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://mastodon.social/tags/Talin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Talin</span></a> <a href="https://mastodon.social/tags/Tau" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tau</span></a> <a href="https://mastodon.social/tags/APP" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>APP</span></a> <a href="https://mastodon.social/tags/photothermal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>photothermal</span></a> <a href="https://mastodon.social/tags/polyaniline" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>polyaniline</span></a> <a href="https://mastodon.social/tags/polydopamine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>polydopamine</span></a> <a href="https://mastodon.social/tags/durability" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>durability</span></a> <a href="https://mastodon.social/tags/thermogalvanic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>thermogalvanic</span></a> <a href="https://mastodon.social/tags/Iron" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Iron</span></a> <a href="https://mastodon.social/tags/scalability" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>scalability</span></a> <a href="https://mastodon.social/tags/stability" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>stability</span></a> <a href="https://mastodon.social/tags/seismometers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>seismometers</span></a> <a href="https://mastodon.social/tags/uncontrolled" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>uncontrolled</span></a> <a href="https://mastodon.social/tags/Chinese" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Chinese</span></a> <a href="https://mastodon.social/tags/SpaceX" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SpaceX</span></a> <a href="https://mastodon.social/tags/damage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>damage</span></a></p>
John Vaccaro (johniac)<p>SciTech Chronicles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .Jan 12, 2025</p><p><a href="https://bit.ly/stc011225" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="">bit.ly/stc011225</span><span class="invisible"></span></a></p><p><a href="https://mastodon.social/tags/TBI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TBI</span></a> <a href="https://mastodon.social/tags/injury" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>injury</span></a>-related #2021 <a href="https://mastodon.social/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>brain</span></a> <a href="https://mastodon.social/tags/function" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>function</span></a> <a href="https://mastodon.social/tags/proton" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>proton</span></a> <a href="https://mastodon.social/tags/irradiation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>irradiation</span></a> <a href="https://mastodon.social/tags/molecules" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>molecules</span></a> <a href="https://mastodon.social/tags/polymers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>polymers</span></a> <a href="https://mastodon.social/tags/Linux" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Linux</span></a> <a href="https://mastodon.social/tags/OS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>OS</span></a> <a href="https://mastodon.social/tags/Distribution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Distribution</span></a> <a href="https://mastodon.social/tags/kernel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>kernel</span></a> <a href="https://mastodon.social/tags/Torvalds" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Torvalds</span></a> <a href="https://mastodon.social/tags/security" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>security</span></a> <a href="https://mastodon.social/tags/CLI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CLI</span></a> <a href="https://mastodon.social/tags/Ultrasound" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Ultrasound</span></a> <a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a>-β <a href="https://mastodon.social/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimer</span></a>’s <a href="https://mastodon.social/tags/Plaques" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Plaques</span></a> <a href="https://mastodon.social/tags/Polar" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Polar</span></a> <a href="https://mastodon.social/tags/Vortex" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Vortex</span></a> <a href="https://mastodon.social/tags/southern" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>southern</span></a> <a href="https://mastodon.social/tags/lobe" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>lobe</span></a> <a href="https://mastodon.social/tags/blocking" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>blocking</span></a></p>
Solar 🌄Garden<p><span class="h-card" translate="no"><a href="https://mastodon.social/@urlyman" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>urlyman</span></a></span> If we can keep our mindsets, and hence perhaps our actual brain tissues bioplastic as we age, then I posit this can become self sustaining: we can learn new thought-routes around those extraneous plastic roadblocks in our head, perhaps even those <a href="https://climatejustice.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> ones. Like the internet, the fediverse, rather than the old ROM-like filling with only one bus-route many are offered during their easy-learn youth.</p>
Lupposofi<p>... and counting. 14 comments thus far, one even from a fellow-guinea-pig with awful experiences. I may have benefited from my own participation (EMERGE, high dose) with few adverse effects, and in any case the general discussion is exciting.</p><p><a href="https://mementomori.social/tags/alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>alzheimer</span></a> <a href="https://mementomori.social/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dementia</span></a> <a href="https://mementomori.social/tags/clinicalResearch" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>clinicalResearch</span></a> <a href="https://mementomori.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a></p>
Lupposofi<p>An interesting open expert question regarding the approval of Alzheimer immuno-therapies on the basis of amyloid-removal alone, <a href="https://www.alzforum.org/news/research-news/it-time-approve-drugs-based-amyloid-removal" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">alzforum.org/news/research-new</span><span class="invisible">s/it-time-approve-drugs-based-amyloid-removal</span></a></p><p>The question is framed with Aisen et.al's open-access article in A & D Perspectives, <a href="https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14342" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">alz-journals.onlinelibrary.wil</span><span class="invisible">ey.com/doi/10.1002/alz.14342</span></a></p><p>The answers may turn out to be the most interesting part, at least with respect to staunch "trenchlines", though both articles contain lots of concise up-to-date information. </p><p>My own interest stems in part from first-hand experience as a guinea-pig in one of those therapies during 2017-22.</p><p><a href="https://mementomori.social/tags/ad" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ad</span></a> <a href="https://mementomori.social/tags/alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>alzheimers</span></a> <a href="https://mementomori.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://mementomori.social/tags/immunothreapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunothreapy</span></a> <a href="https://mementomori.social/tags/drugs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>drugs</span></a> <a href="https://mementomori.social/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dementia</span></a> <a href="https://mementomori.social/tags/query" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>query</span></a> <a href="https://mementomori.social/tags/alzForum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>alzForum</span></a> <a href="https://mementomori.social/tags/clinical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>clinical</span></a> <a href="https://mementomori.social/tags/neurology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neurology</span></a> <a href="https://mementomori.social/tags/geriatrics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>geriatrics</span></a> <a href="https://mementomori.social/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a></p>
Penny Richards<p>started a <a href="https://mastodon.world/tags/wikipedia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>wikipedia</span></a> article on biochemist Lawreen Connors (1954-2024), director of the Amyloidosis Center at Boston University: <a href="https://en.wikipedia.org/wiki/Lawreen_Connors" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">en.wikipedia.org/wiki/Lawreen_</span><span class="invisible">Connors</span></a> <span class="h-card" translate="no"><a href="https://bird.makeup/users/wikiwomeninred" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>wikiwomeninred</span></a></span> <a href="https://mastodon.world/tags/WomeninSTEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>WomeninSTEM</span></a> <a href="https://mastodon.world/tags/BostonUniversity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BostonUniversity</span></a> <span class="h-card" translate="no"><a href="https://bird.makeup/users/bostoncollege" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>bostoncollege</span></a></span> <span class="h-card" translate="no"><a href="https://bird.makeup/users/tuftsuniversity" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>tuftsuniversity</span></a></span> <a href="https://mastodon.world/tags/WoburnMA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>WoburnMA</span></a> <a href="https://mastodon.world/tags/OgdensburgNY" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>OgdensburgNY</span></a> <a href="https://mastodon.world/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://mastodon.world/tags/amyloidosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloidosis</span></a> <a href="https://mastodon.world/tags/Diedin2024" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Diedin2024</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>Will this be the death knell for Alzheimer’s monoclonal antibody treatments 🤔</p><p>Preprint on <a href="https://vmst.io/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a> drug deaths ignites dispute among authors</p><p>“Infighting among a group of prominent Alzheimer’s disease researchers has led to the withdrawal of a preprint they co-authored, which suggested a new Alzheimer’s drug markedly increases the risk of death. One scientist involved in the work charges the senior author failed to seek the go-ahead from his co-authors before posting an edited version of the article to a preprint server.”<br> <br><a href="https://vmst.io/tags/Lecanemab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lecanemab</span></a> <a href="https://vmst.io/tags/Donanemab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Donanemab</span></a> <a href="https://vmst.io/tags/Kisunla" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Kisunla</span></a> <a href="https://vmst.io/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://vmst.io/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dementia</span></a><br><a href="https://www.science.org/content/article/preprint-alzheimer-s-drug-deaths-ignites-dispute-among-authors" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/content/article/pr</span><span class="invisible">eprint-alzheimer-s-drug-deaths-ignites-dispute-among-authors</span></a></p>
Patrick van der Wel<p>Secondary nucleation is increasing recognized as a dominant process in protein aggregation, and in particular also for pathogenic (disease causing) proteins. Still, many questions remain about how this process works, and what implications it has for pathogenic mechanisms. Here we show the unique power of HS-AFM to actually visualize this process directly. Check it out!</p><p><a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://mastodon.social/tags/AFM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AFM</span></a> <a href="https://mastodon.social/tags/huntingtonsdisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>huntingtonsdisease</span></a> (2/2)</p>
Rhyothemis<p>related, from 2012:</p><p>Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands<br><a href="https://pubmed.ncbi.nlm.nih.gov/22549788/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pubmed.ncbi.nlm.nih.gov/225497</span><span class="invisible">88/</span></a></p><p>"Although serum albumin has an established function as a transport protein, evidence is emerging that serum albumin may also have a role as a molecular chaperone. Using established techniques to characterize chaperone interactions, this study demonstrates that bovine serum albumin: 1) preferentially binds stressed over unstressed client proteins; 2) forms stable, soluble, high molecular weight complexes with stressed client proteins; 3) reduces the aggregation of client proteins when it is present at physiological levels; and 4) inhibits amyloid formation by both WT and L55P transthyretin. Although the antiaggregatory effect of serum albumin is maintained in the presence of physiological levels of Ca(2+) and Cu(2+), the presence of free fatty acids significantly alters this activity: stabilizing serum albumin at normal levels but diminishing chaperone-like activity at high concentrations. Moreover, here it is shown that depletion of albumin from human plasma leads to a significant increase in aggregation under physiologically relevant heat and shear stresses. This study demonstrates that serum albumin possesses chaperone-like properties and that this activity is maintained under a number of physiologically relevant conditions."</p><p><a href="https://zeroes.ca/tags/albumin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>albumin</span></a> <a href="https://zeroes.ca/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a></p>
Matt Willemsen<p>Amyloids May Not Cause Alzheimer’s: Quantum Effect in the Brain Challenges Conventional Wisdom<br><a href="https://scitechdaily.com/amyloids-may-not-cause-alzheimers-quantum-effect-in-the-brain-challenges-conventional-wisdom/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">scitechdaily.com/amyloids-may-</span><span class="invisible">not-cause-alzheimers-quantum-effect-in-the-brain-challenges-conventional-wisdom/</span></a><br><a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://mastodon.social/tags/alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>alzheimers</span></a> <a href="https://mastodon.social/tags/BrainHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>BrainHealth</span></a> <a href="https://mastodon.social/tags/quantum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>quantum</span></a> <a href="https://mastodon.social/tags/superradiance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>superradiance</span></a> <a href="https://mastodon.social/tags/AmyloidFibrils" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AmyloidFibrils</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>Alzheimer's Gets a New Definition</p><p>“In the revised criteria, the committee outlined three broad categories of biomarkers: those specific to <a href="https://vmst.io/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimer</span></a>'s changes like <a href="https://vmst.io/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> and tau, referred to as "core" biomarkers; those important to <a href="https://vmst.io/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a> but not specific to the disease, like neurodegeneration and inflammation; and those that reflect conditions that commonly co-exist with Alzheimer's, like vascular pathology and alpha-synuclein.”</p><p><a href="https://www.medpagetoday.com/neurology/alzheimersdisease/110912" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">medpagetoday.com/neurology/alz</span><span class="invisible">heimersdisease/110912</span></a></p>
Skip Lacaze<p><span class="h-card" translate="no"><a href="https://mastodon.social/@CStamp" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>CStamp</span></a></span> <span class="h-card" translate="no"><a href="https://mstdn.social/@DemocracyMattersALot" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>DemocracyMattersALot</span></a></span> This will be important for many people already dealing with memory issues or with family members showing possible signs of <a href="https://sfba.social/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dementia</span></a>, however it is still limited by lack of any real treatment options. The closing paragraph says, “For people without memory loss who are worried about genetic or familial <a href="https://sfba.social/tags/Alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimers</span></a> risk, blood tests are not yet recommended. <a href="https://sfba.social/tags/Amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Amyloid</span></a> buildup can begin decades before symptoms appear, and no preventive treatments are currently available apart from general guidelines about healthy eating and living.”</p>
trendless 🇨🇦 :flag_AB:<p><a href="https://portlandpress.com/biochemj/article/479/4/537/230829/A-central-role-for-amyloid-fibrin-microclots-in?s=09" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">portlandpress.com/biochemj/art</span><span class="invisible">icle/479/4/537/230829/A-central-role-for-amyloid-fibrin-microclots-in?s=09</span></a></p><p>> Although the symptoms of Long COVID are multifarious, we here argue that the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms. Consistent with this, in a preliminary report, it has been shown that suitable and closely monitored ‘triple’ anticoagulant therapy that leads to the removal of the microclots also removes the other symptoms.</p><p><a href="https://zeroes.ca/tags/LongCovid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>LongCovid</span></a> <a href="https://zeroes.ca/tags/Amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Amyloid</span></a> <a href="https://zeroes.ca/tags/Fibrin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Fibrin</span></a> <a href="https://zeroes.ca/tags/MicroClots" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MicroClots</span></a> <a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CovidIsNotOver</span></a></p>
Matt Willemsen<p>When Heart Failure Is Actually Cardiac Amyloidosis<br><a href="https://www.medscape.com/viewarticle/when-heart-failure-actually-cardiac-amyloidosis-2024a1000blr?src=rss&icd=login_success_email_match_norm" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">medscape.com/viewarticle/when-</span><span class="invisible">heart-failure-actually-cardiac-amyloidosis-2024a1000blr?src=rss&icd=login_success_email_match_norm</span></a> <a href="https://mastodon.social/tags/TransthyretinAmyloidosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TransthyretinAmyloidosis</span></a> <a href="https://mastodon.social/tags/ATTR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ATTR</span></a> <a href="https://mastodon.social/tags/heart" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>heart</span></a> <a href="https://mastodon.social/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> <a href="https://mastodon.social/tags/protein" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>protein</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>Do we have <a href="https://vmst.io/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimer</span></a>’s disease all wrong?</p><p>“As Science noted in its story on the retracted paper, scientists are still debating whether the <a href="https://vmst.io/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> theory is viable. The skeptics cite the fraudulent research and lack of a genuine breakthrough; supporters can point to this new class of drugs including <a href="https://vmst.io/tags/donanemab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>donanemab</span></a> that have led to some improvement in some patients.”</p><p> <a href="https://www.vox.com/future-perfect/355108/alzheimers-disease-drug-approval-research-retraction" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">vox.com/future-perfect/355108/</span><span class="invisible">alzheimers-disease-drug-approval-research-retraction</span></a></p>
DrBob, Neurologist, 🧠Mechanic<p>Two Is Better Than One in the Alzheimer’s Market </p><p>“Last week, a panel of independent advisers to the FDA unanimously voted in support of Eli Lilly’s <a href="https://vmst.io/tags/donanemab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>donanemab</span></a>, a competitor in the same class of drugs that target <a href="https://vmst.io/tags/amyloid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>amyloid</span></a> plaques in the brain. The <a href="https://vmst.io/tags/FDA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>FDA</span></a> is expected to decide on whether to approve the drug by the end of the year.</p><p>Life expectancies around the world have surged in recent decades, increasingly putting people at risk of <a href="https://vmst.io/tags/dementia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>dementia</span></a>. About one in nine seniors has <a href="https://vmst.io/tags/Alzheimer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Alzheimer</span></a>’s disease, the most common cause of the condition, which works out to some seven million Americans.”</p><p><a href="https://finance.yahoo.com/news/two-better-one-alzheimer-market-110000384.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">finance.yahoo.com/news/two-bet</span><span class="invisible">ter-one-alzheimer-market-110000384.html</span></a></p>
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