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#longevity

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How to eat to stay healthy at 70? 💪 A 30-year study of over 100,000 Americans says: eat your fruits, veggies, whole grains, nuts, and healthy fats – and go easy on salty meats, trans fats, and sugary drinks.

:doi: doi.org/10.1038/s41591-025-035

Coffee lovers get a (non)neutral update – coffee ranks somewhere in the middle.

In war-torn Ukraine, male life expectancy has dropped from 66 to 57.

Zusammenhänge zwischen epigenetischer Alterung und COVID-19: Eine 3-jährige Längsschnittstudie.

#Corona lässt euch schneller altern.

link.springer.com/article/10.1

SpringerLinkAssociations of epigenetic aging and COVID- 19: A 3-year longitudinal study - GeroScienceAging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging and the risk of disease. The physiological functions of 54 volunteers—including maximal oxygen uptake (VO₂ max), grip strength, and vertical jump—were assessed just before the COVID- 19 pandemic and again 3 years later. Of these volunteers, 27 had contracted COVID- 19. Eight epigenetic clocks were used to assess the rate of aging during the 3-year period: DNAmAge showed accelerated aging, and five clocks showed slowed aging (DNAmAgeSkinBlood, DNAmAgeHannum, DNAmFitAge, PhenoAge, and DNAmTL). When we considered only females, we observed a stronger effect in the increase of DNAmAge acceleration, while we observed slowed aging in the case of SkinBloodClock, and DNAmTL. The methylation of the promoter region of the H1 FNT genes, which encodes testis-specific histone H1 family member N (H1fnt) and plays a crucial role in spermatogenesis decreased the most significantly. In contrast, the promoter of CSTL1, which encodes Cystatin-like 1, showed the most significant increase. We found that having COVID- 19 during the 3-year study period significantly increased the progress of aging assessed by DNAmGrimAge, DNAmGrimAge2, and DNAmFitAge (p = 0.024, 0.047, 0.032, respectively, after we adjusted the analysis for baseline variables). The data suggest that COVID- 19 may have a mild long-term effect on epigenetic aging.
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@erictopol

I normally ignore the NYT because of their ongoing sanewashing of Trump and his fellow travellers, but this is by Eric Topol.

"Getting an injection of youthful blood or taking the latest trendy anti-aging supplement might seem like a shortcut to a longer life. But extending the years people live without the burden of major age-related diseases is what should be a national priority."

Continued thread
Replied in thread

@bruces
FFS, Wired, cut that clickbait BS.
We are, as are many other animals. After you produce enough progeny #selection doesn't give a shit about your #longevity anymore and entropy takes over. Every biologist with even a rudimentary #ecology training knows that.

The problem that we're not programmed in a way "there is something which get switched on and you die", that would be easy, it's "many things go out of control, you die unless you fix _all of them_".